I study maternal-fetal health, with a focus on placental function in hypertensive disorders of pregnancy, such as preeclampsia. My research investigates how omega-3 fatty acid derivatives, specifically Resolvin D2 (RvD2), can improve placental health.
In preeclamptic and hypertensive placentas, mitochondrial dysfunction and reduced nitric oxide (NO) availability contribute to impaired vascular function and oxidative stress. My work demonstrates that RvD2 enhances nitric oxide bioavailability and supports mitochondrial function, helping to restore balance in the placenta.
Most recently, my publication showed that RvD2 acts as a positive endogenous potentiator to promote antioxidants within the placenta, highlighting its therapeutic potential to reduce oxidative stress, improve vascular signaling, and ultimately promote healthier maternal-fetal outcomes.
Current Students:
Collaboration: Many thanks to my collaborators and mentors throughout the years.
Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review
Hahka TM, Slotkowski RA, Akbar A, VanOrmer MC, Sembajwe LF, Ssekandi AM, Namaganda A, Muwonge H, Kasolo JN, Nakimuli A, Mwesigwa N, Ishimwe JA, Kalyesubula R, Kirabo A, Anderson Berry AL, Patel KP
RvD2 mitigates TNFɑ-Induced mitochondrial reactive oxygen species through NRF2 signaling in placental trophoblasts
Hahka T, Sekar D, Sahoo PK, Ravi A, Freel C, Krishnamoorthy C, Ramamurthy S, Rapoza R, Drakowski R, Akbar A, VanOrmer M, Thoene M, Hanson CK, Nordgren T, Natarajan SK, Anderson Berry A.